Gene: [02^/TSE2] tissue specific extinguisher 2;
|
COM |
Tissue-specific gene expression is generally extinguished in somatic
cell hybrids formed by fusing different cell types. The extinction
phenomenon has been long studied as a paradigm for developmental and
tissue-specific gene control. The extinction in
hepatoma/fibroblast hybrids involves a comprehensive loss of
liver-specific gene activity, including expression of liver-enriched
transcription factors. Extinction of liver gene expression in hepatoma
hybrids occurs at the level of transcription, resulting in a 1,000-fold
reduction in steady-state levels of liver-specific mRNAs. Furthermore,
extinction is reversible: as the hybrids segregate chromosomes of their
nonhepatic parents, liver genes are reexpressed. Thus, extinction is an
active process that requires the continuous presence of fibroblast loci
that function in trans (Cerosaletti-1996). Cerosaletti and Fournier
(1996) favored the view that multiple extinguisher loci reside on human chromosome 2." |
|
FAG |
The product of the TSE1 locus was identified as the the regulatory subunit RI-alpha of protein kinase A (GEM:17q2/PRKAR1A)." |
|
REF |
LOC,REV "Cerosaletti KM, Fournier REK: Genomics, 31, 348-358, 1996 |
|
KEY |
trc |
|
CLA |
coding, basic |
|
LOC |
02 |
|
MIM |
MIM: 601136 |
